:root {
  --ink: #173c35;
  --ink-soft: #47665f;
  --paper: #f4f1e8;
  --paper-deep: #e9e4d8;
  --line: #d1cec2;
  --lime: #c8ef65;
  --orange: #ef704b;
  --white: #fffdf6;
  --mono: "SFMono-Regular", Consolas, "Liberation Mono", monospace;
  --sans: Inter, "Avenir Next", Avenir, Helvetica, Arial, sans-serif;
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body { margin: 0; background: var(--paper); color: var(--ink); font-family: var(--sans); }
button, input, select { font: inherit; }
button { color: inherit; }
button:focus-visible, input:focus-visible, select:focus-visible, a:focus-visible { outline: 3px solid var(--orange); outline-offset: 3px; }

.masthead {
  align-items: center;
  background: var(--paper);
  border-bottom: 1px solid var(--line);
  display: flex;
  justify-content: space-between;
  margin: 0 3vw;
  min-height: 78px;
  position: sticky;
  top: 0;
  z-index: 10;
}
.wordmark { align-items: center; color: var(--ink); display: flex; font-size: 13px; font-weight: 700; gap: 10px; letter-spacing: .18em; text-decoration: none; }
.wordmark-mark { align-items: center; background: var(--ink); border-radius: 50%; color: var(--lime); display: flex; font-family: serif; font-size: 17px; height: 30px; justify-content: center; width: 30px; }
.site-tabs { align-self: stretch; display: flex; }
.site-tabs button { background: transparent; border: 0; border-left: 1px solid var(--line); cursor: pointer; font-family: var(--mono); font-size: 9px; letter-spacing: .08em; padding: 0 18px; text-transform: uppercase; }
.site-tabs button[aria-selected="true"] { background: var(--ink); color: var(--lime); }
.controls-dialog { background: var(--white); border: 1px solid var(--ink); color: var(--ink); max-height: min(680px, 85dvh); padding: 0; width: min(620px, 90vw); }
.controls-dialog::backdrop { background: rgb(23 60 53 / 45%); }
.controls-heading { align-items: center; border-bottom: 1px solid var(--ink); display: flex; justify-content: space-between; padding: 20px 24px; }
.controls-heading h2 { font-size: 24px; font-weight: 600; letter-spacing: -.03em; margin: 0; }
.controls-close { background: transparent; border: 0; cursor: pointer; font-size: 24px; line-height: 1; padding: 0 0 0 20px; }
.control-scopes { display: grid; gap: 0; max-height: calc(85dvh - 70px); overflow-y: auto; }
.control-scope { border-bottom: 1px solid var(--line); display: grid; gap: 16px; grid-template-columns: 150px 1fr; opacity: .48; padding: 18px 24px; }
.control-scope:last-child { border-bottom: 0; }
.control-scope.active { opacity: 1; }
.control-scope h3 { font-family: var(--mono); font-size: 9px; letter-spacing: .08em; margin: 4px 0 0; text-transform: uppercase; }
.control-scope.active h3::after { color: var(--orange); content: "Active"; display: block; font-size: 7px; margin-top: 6px; }
.control-scope dl { display: grid; gap: 10px 14px; grid-template-columns: 120px 1fr; margin: 0; }
.control-scope dt, .control-scope dd { font-size: 12px; margin: 0; }
.control-scope kbd { background: var(--paper); border: 1px solid var(--line); border-bottom-color: var(--ink-soft); border-radius: 3px; display: inline-block; font-family: var(--mono); min-width: 32px; padding: 3px 6px; text-align: center; }
footer p { font-family: var(--mono); font-size: 10px; letter-spacing: .08em; text-transform: uppercase; }
.controls-help { background: transparent; border: 0; color: var(--ink); cursor: pointer; font-family: var(--mono); font-size: 10px; margin-left: auto; padding: 0; text-decoration: underline; text-decoration-color: var(--orange); text-underline-offset: 3px; }
.controls-help:hover { color: var(--orange); }
main { overflow: hidden; }

.panel { border-bottom: 1px solid var(--line); padding: 24px 5vw 48px; scroll-margin-top: 78px; }
.swipe-surface { touch-action: pan-y pinch-zoom; }
.panel.timeline-panel { padding-left: 0; padding-right: 0; }
.viz-controls { border-bottom: 1px solid var(--line); border-top: 1px solid var(--line); display: flex; justify-content: end; margin: 0 auto 24px; max-width: 1100px; }
.viz-controls label { display: grid; gap: 4px; min-width: 190px; padding: 8px 10px; }
.viz-controls label + label { border-left: 1px solid var(--line); }
.viz-controls label > span { color: var(--ink-soft); font-family: var(--mono); font-size: 8px; letter-spacing: .08em; text-transform: uppercase; }
.viz-controls select { background: transparent; border: 0; color: var(--ink); cursor: pointer; font-size: 11px; min-width: 0; padding: 0 24px 0 0; width: 100%; }
.timeline-controls { margin: 0 3vw 16px; max-width: none; }
.timeline { border-bottom: 1px solid var(--ink); border-top: 1px solid var(--ink); }
.timeline-chart { margin: 0; padding: 18px 0 4px; }
.timeline-chart-scroll { overflow-x: auto; }
.timeline-chart svg { display: block; height: 360px; min-width: 720px; width: 100%; }
.timeline-grid { stroke: var(--line); stroke-width: 1; }
.timeline-area { fill-opacity: .72; }
.timeline-line { fill: none; stroke: var(--orange); stroke-linecap: round; stroke-linejoin: round; stroke-width: 3; }
.timeline-point circle { fill: var(--paper); stroke: var(--ink); stroke-width: 2; }
.timeline-point:focus { outline: none; }
.timeline-point:hover circle, .timeline-point:focus circle { fill: var(--lime); stroke: var(--orange); stroke-width: 3; }
.visualization-tooltip { background: var(--ink); border: 1px solid var(--lime); color: var(--white); font-family: var(--mono); font-size: 10px; line-height: 1.45; max-height: min(70dvh, 520px); overflow-y: auto; padding: 10px 12px; position: fixed; width: min(320px, calc(100vw - 20px)); z-index: 40; }
.visualization-tooltip-summary { display: grid; gap: 3px; }
.visualization-tooltip-summary strong { color: var(--lime); font-family: var(--sans); font-size: 13px; }
.visualization-tooltip-summary span { color: var(--white); }
.visualization-tooltip-item-heading { border-top: 1px solid rgb(255 253 246 / 28%); display: flex; justify-content: space-between; letter-spacing: .08em; margin-top: 9px; padding-top: 8px; text-transform: uppercase; }
.visualization-tooltip-item-heading small { color: var(--lime); font: inherit; }
.visualization-tooltip-items { display: grid; gap: 3px; list-style: none; margin: 6px 0 0; padding: 0; }
.visualization-tooltip-items li { display: grid; gap: 16px; grid-template-columns: minmax(0, 1fr) auto; overflow-wrap: anywhere; }
.visualization-tooltip-items strong { color: var(--lime); font-weight: 400; text-align: right; white-space: nowrap; }
.timeline-x-label, .timeline-y-label { fill: var(--ink-soft); font-family: var(--mono); font-size: 9px; }
.timeline-x-label { text-anchor: end; }
.timeline-y-label { text-anchor: end; }
.timeline-dimension-legend { display: flex; flex-wrap: wrap; gap: 7px 16px; max-height: 92px; overflow-y: auto; padding: 0 3vw 14px; }
.timeline-legend-entry { align-items: center; background: transparent; border: 0; color: var(--ink); display: inline-flex; font-family: var(--mono); font-size: 8px; gap: 6px; padding: 0; text-align: left; }
button.timeline-legend-entry { cursor: pointer; text-decoration: underline; text-decoration-color: var(--orange); text-underline-offset: 3px; }
.timeline-legend-entry i { flex: 0 0 auto; height: 8px; width: 8px; }

.filter-region { padding: 16px 5vw 0; scroll-margin-top: 78px; }
.global-filters { border-bottom: 1px solid var(--ink); border-top: 1px solid var(--ink); display: grid; grid-template-columns: repeat(5, minmax(0, 1fr)) minmax(190px, 1.25fr) minmax(190px, auto); }
.global-filters > * { border-right: 1px solid var(--line); }
.global-filters > :last-child { border-right: 0; }
.filter-control { display: flex; flex-direction: column; min-width: 0; padding: 8px 10px; position: relative; }
.filter-label { color: var(--ink-soft); font-family: var(--mono); font-size: 8px; letter-spacing: .08em; text-transform: uppercase; }
.filter-control > select, .filter-multiselect summary { background: transparent; border: 0; color: var(--ink); font-size: 11px; height: 30px; line-height: 30px; min-width: 0; padding: 0; width: 100%; }
.filter-control > select { cursor: pointer; }
.filter-multiselect { min-width: 0; }
.filter-multiselect summary { cursor: pointer; list-style-position: inside; overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.filter-popover { background: var(--white); border: 1px solid var(--ink); box-shadow: 0 12px 30px rgb(23 60 53 / 18%); left: -1px; min-width: max(100%, 240px); padding: 10px; position: absolute; top: calc(100% - 5px); z-index: 15; }
.filter-popover > input { background: var(--paper); border: 1px solid var(--line); color: var(--ink); font-size: 11px; padding: 8px; width: 100%; }
.filter-selection-actions { display: flex; gap: 12px; justify-content: space-between; padding: 8px 3px 4px; }
.filter-selection-actions button { background: transparent; border: 0; cursor: pointer; font-family: var(--mono); font-size: 8px; padding: 0; text-decoration: underline; text-decoration-color: var(--orange); text-underline-offset: 3px; text-transform: uppercase; }
.filter-options { display: grid; gap: 1px; margin-top: 7px; max-height: 220px; overflow-y: auto; }
.filter-option { align-items: center; display: grid; grid-template-columns: minmax(0, 1fr) auto; }
.filter-option[hidden] { display: none; }
.filter-option:hover, .filter-option:focus-within { background: var(--paper); }
.filter-option label { align-items: center; cursor: pointer; display: flex; font-size: 11px; gap: 8px; min-width: 0; padding: 6px; }
.filter-options input { accent-color: var(--orange); margin: 0; }
.filter-select-only { background: transparent; border: 0; cursor: pointer; font-family: var(--mono); font-size: 8px; opacity: 0; padding: 6px; text-decoration: underline; text-decoration-color: var(--orange); text-underline-offset: 3px; text-transform: uppercase; }
.filter-option:hover .filter-select-only, .filter-option:focus-within .filter-select-only { opacity: 1; }
.number-filter output { font-family: var(--mono); font-size: 8px; line-height: 30px; white-space: nowrap; }
.number-filter-sliders { background: linear-gradient(to right, var(--paper-deep) 0 var(--range-start), var(--orange) var(--range-start) var(--range-end), var(--paper-deep) var(--range-end) 100%); height: 4px; margin-top: -2px; position: relative; }
.number-filter-sliders input { appearance: none; background: transparent; height: 4px; margin: 0; pointer-events: none; position: absolute; width: 100%; }
.number-filter-sliders input::-webkit-slider-runnable-track { background: transparent; height: 4px; }
.number-filter-sliders input::-webkit-slider-thumb { appearance: none; background: var(--ink); border: 2px solid var(--paper); border-radius: 50%; cursor: grab; height: 14px; margin-top: -5px; pointer-events: auto; width: 14px; }
.number-filter-sliders input::-moz-range-track { background: transparent; height: 4px; }
.number-filter-sliders input::-moz-range-thumb { background: var(--ink); border: 2px solid var(--paper); border-radius: 50%; cursor: grab; height: 10px; pointer-events: auto; width: 10px; }
.filter-actions { align-items: center; display: flex; gap: 12px; justify-content: space-between; padding: 10px 14px; }
.filter-actions output { font-family: var(--mono); font-size: 9px; white-space: nowrap; }
.filter-actions button { background: transparent; border: 0; color: var(--ink); cursor: pointer; font-family: var(--mono); font-size: 9px; letter-spacing: .06em; padding: 0; text-transform: uppercase; }
.filter-actions button:hover { color: var(--orange); }
.table-scroll { overflow-x: auto; }
.approval-table { border-collapse: collapse; font-size: 11px; width: 100%; }
.approval-table th { border-bottom: 1px solid var(--ink); color: var(--ink-soft); font-family: var(--mono); font-size: 8px; letter-spacing: .08em; padding: 0; text-align: left; text-transform: uppercase; white-space: nowrap; }
.approval-table th button { background: transparent; border: 0; cursor: pointer; padding: 12px 10px; text-align: inherit; width: 100%; }
.approval-table th[aria-sort="ascending"] button::after { content: " ↑"; color: var(--orange); }
.approval-table th[aria-sort="descending"] button::after { content: " ↓"; color: var(--orange); }
.approval-table td { border-bottom: 1px solid var(--line); padding: 12px 10px; vertical-align: top; }
.approval-table td:first-child { font-family: var(--mono); font-size: 9px; white-space: nowrap; }
.approval-table .number { text-align: right; white-space: nowrap; }
.entity-link { background: transparent; border: 0; cursor: pointer; font-weight: 700; padding: 0; text-align: left; text-decoration: underline; text-decoration-color: var(--orange); text-underline-offset: 3px; }
.entity-link:hover { color: var(--orange); }
.filter-datum { background: transparent; border: 0; cursor: pointer; padding: 0; text-align: inherit; text-decoration: underline; text-decoration-color: var(--orange); text-decoration-style: dotted; text-underline-offset: 3px; }
.filter-datum:hover { color: var(--orange); }
.table-empty { color: var(--ink-soft); font-family: var(--mono); padding: 42px 10px !important; text-align: center; }
.visualization-empty { color: var(--ink-soft); font-family: var(--mono); font-size: 10px; margin: 0; padding: 42px 0; text-align: center; }

.market-share-chart { align-items: center; display: grid; gap: 36px 6vw; grid-template-columns: minmax(300px, .8fr) minmax(360px, 1.2fr); margin: 0 auto; max-width: 1100px; }
.market-share-chart svg { display: block; margin: auto; max-height: 520px; width: min(100%, 520px); }
.market-share-slice { stroke: var(--paper); stroke-width: 2; }
.market-share-slice:hover, .market-share-slice:focus { filter: brightness(1.16); outline: none; stroke: var(--orange); stroke-width: 4; }
.market-share-legend { display: grid; gap: 1px; max-height: 440px; overflow-y: auto; }
.market-share-legend-entry { align-items: center; background: transparent; border: 0; color: var(--ink); display: grid; font-size: 11px; gap: 10px; grid-template-columns: 9px minmax(120px, 1fr) auto 48px; padding: 7px 8px; text-align: left; width: 100%; }
button.market-share-legend-entry { cursor: pointer; }
.market-share-legend-entry:hover, .market-share-legend-entry:focus-visible { background: var(--white); }
.market-share-legend-entry i { height: 9px; width: 9px; }
.market-share-legend-entry strong, .market-share-legend-entry small { font-family: var(--mono); font-size: 9px; font-weight: 400; text-align: right; }
.market-share-legend-entry small { color: var(--ink-soft); }
.center-badge { border: 1px solid currentColor; border-radius: 20px; font-family: var(--mono); font-size: 8px; letter-spacing: .08em; padding: 5px 8px; }
.center-badge.cber { color: #c64d2e; }
.detail-panel-backdrop { background: rgb(23 60 53 / 35%); inset: 0; opacity: 0; pointer-events: none; position: fixed; transition: opacity .2s ease, visibility .2s; visibility: hidden; z-index: 20; }
.detail-panel { background: var(--white); border-left: 1px solid var(--ink); box-shadow: -18px 0 50px rgb(23 60 53 / 18%); height: 100dvh; max-width: 100%; position: fixed; right: 0; top: 0; transform: translateX(100%); transition: transform .24s ease, visibility .24s; visibility: hidden; width: min(1200px, 82vw); z-index: 30; }
.detail-panel-open { overflow: hidden; }
.detail-panel-open .detail-panel-backdrop { opacity: 1; pointer-events: auto; visibility: visible; }
.detail-panel-open .detail-panel { transform: translateX(0); visibility: visible; }
.detail-panel-scroll { height: 100%; overflow-y: auto; padding: 24px 34px 56px; }
.detail-panel-close { background: transparent; border: 0; cursor: pointer; display: block; font-family: var(--mono); font-size: 9px; letter-spacing: .06em; margin-left: auto; padding: 4px 0 28px 20px; text-transform: uppercase; }
.detail-panel-close span { font-family: var(--sans); font-size: 18px; margin-left: 5px; vertical-align: -2px; }
.detail-panel-close:hover { color: var(--orange); }
.detail-panel-title { font-size: clamp(38px, 5vw, 70px); font-weight: 500; letter-spacing: -.06em; line-height: 1; margin: 0 0 32px; overflow-wrap: anywhere; }
.detail-metadata { border-top: 1px solid var(--ink); display: grid; grid-template-columns: 1fr 1fr; margin: 0; }
.detail-metadata > div { border-bottom: 1px solid var(--line); min-width: 0; padding: 14px 16px 16px 0; }
.detail-metadata .detail-left { border-right: 1px solid var(--line); }
.detail-metadata .detail-right { padding-left: 16px; }
.detail-metadata .detail-wide { border-right: 0; grid-column: 1 / -1; padding-left: 0; }
.drug-detail-metadata { grid-template-columns: repeat(var(--detail-columns), minmax(0, 1fr)); }
.drug-detail-metadata > div, .drug-detail-metadata .detail-left, .drug-detail-metadata .detail-right, .drug-detail-metadata .detail-wide { border-right: 1px solid var(--line); grid-column: auto; padding: 14px 14px 16px; }
.drug-detail-metadata > div:first-child { padding-left: 0; }
.drug-detail-metadata > div:last-child { border-right: 0; padding-right: 0; }
.detail-metadata dt { color: var(--ink-soft); font-family: var(--mono); font-size: 8px; letter-spacing: .08em; margin-bottom: 7px; text-transform: uppercase; }
.detail-metadata dd { font-size: 13px; line-height: 1.5; margin: 0; overflow-wrap: anywhere; }
.detail-metadata code { font-family: var(--mono); font-size: 10px; }
.detail-rule { background: var(--orange); height: 4px; margin: 30px 0; width: 42px; }
.detail-report-heading { font-size: 22px; font-weight: 600; letter-spacing: -.025em; margin: 0 0 12px; }
.detail-entity-list { display: flex; flex-wrap: wrap; gap: 8px 16px; margin: 0 0 30px; }
.detail-report { font-size: 15px; line-height: 1.75; margin: 0; width: 100%; }
.detail-report a { color: var(--ink); font-weight: 700; text-decoration-color: var(--orange); text-decoration-thickness: 2px; text-underline-offset: 3px; }
footer { border-top: 1px solid var(--line); display: flex; justify-content: space-between; margin: 0 3vw; padding: 32px 2vw 45px; }
.sr-only { height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; clip: rect(0, 0, 0, 0); white-space: nowrap; }

@media (max-width: 900px) {
  .panel { min-height: 0; }
  .global-filters { grid-template-columns: 1fr 1fr; }
  .global-filters > * { border-bottom: 1px solid var(--line); border-right: 1px solid var(--line); }
  .global-filters > :nth-child(2n) { border-right: 0; }
  .global-filters > :nth-child(n+7) { border-bottom: 0; }
  .market-share-chart { grid-template-columns: 1fr; }
  .drug-detail-metadata { grid-template-columns: repeat(3, 1fr); }
  .drug-detail-metadata > div:nth-child(3n+1) { padding-left: 0; }
  .drug-detail-metadata > div:nth-child(3n) { border-right: 0; }
}

@media (max-width: 700px) {
  .viz-controls { display: grid; grid-template-columns: 1fr; }
  .viz-controls label { min-width: 0; }
  .viz-controls label + label { border-left: 0; border-top: 1px solid var(--line); }
  .timeline-controls { margin-left: 6vw; margin-right: 6vw; }
}

@media (max-width: 600px) {
  .masthead { min-height: 64px; }
  .wordmark > span:last-child { display: none; }
  .site-tabs button { font-size: 8px; padding: 0 9px; }
  .control-scope { grid-template-columns: 1fr; }
  .filter-region, .panel { scroll-margin-top: 64px; }
  .filter-region { padding: 12px 5vw 0; }
  .panel { padding: 20px 6vw 40px; }
  .global-filters { grid-template-columns: 1fr; }
  .global-filters > *, .global-filters > :nth-child(2n), .global-filters > :nth-child(n+7) { border-bottom: 1px solid var(--line); border-right: 0; }
  .global-filters > :last-child { border-bottom: 0; min-height: 50px; }
  .center-badge { font-size: 7px; padding: 4px 6px; }
  .detail-panel { border-left: 0; width: 100%; }
  .detail-panel-scroll { padding: 20px 5vw 48px; }
  .detail-metadata { grid-template-columns: 1fr; }
  .detail-metadata > div, .detail-metadata .detail-right, .detail-metadata .detail-wide { border-right: 0; grid-column: auto; padding-left: 0; }
  .drug-detail-metadata > div, .drug-detail-metadata .detail-left, .drug-detail-metadata .detail-right, .drug-detail-metadata .detail-wide { border-right: 0; padding-left: 0; padding-right: 0; }
  footer { align-items: start; flex-direction: column; gap: 8px; }
}

@media (hover: none) {
  .filter-select-only { opacity: 1; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { transition-duration: .01ms !important; }
}